九九精品99久久久香蕉,xx欧美肥臀,中国国语毛片免费观看视频,久久av高潮av无码av

當前位置:首頁  >  技術(shù)文章  >  利用負載阿霉素的金屬有機框架涂層磁性納米顆粒精準治療結(jié)腸癌

利用負載阿霉素的金屬有機框架涂層磁性納米顆粒精準治療結(jié)腸癌

更新時間:2025-01-27  |  點擊率:125

20249月,浙江大學材料科學與工程學院;伊利諾伊大學芝加哥分校藥學院藥學系;浙江大學動物科學學院應用生物資源研究所,浙江蠶蜂資源利用與創(chuàng)新重點實驗室 (School of Materials Science &Engineering,Zhejiang University, Hangzhou, Zhejiang 310027, China;Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, 60607, United StatesKey Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province,Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058,China;) Honglin Jiang老師研究團隊在《Acs Applied Materials & Interfaces》上發(fā)表論文:

Precision Treatment of Colon Cancer Using Doxorubicin-Loaded Metal-Organic-Framework-Coated Magnetic Nanoparticles"

 

“利用負載阿霉素的金屬有機框架涂層磁性納米顆粒精準治療結(jié)腸癌"

 

Abstract

Due to the limited efficacy and evident side effects of traditional chemotherapy drugs attributed to their lack of specificity and selectivity, novel strategies are essential for improving cancer treatment outcomes. Here, we successfully engineered Fe3O4 magnetic nanoparticles coated with zeolitic imidazolate framework-8 (ZIF-8). The resulting nanocomposite (Fe3O4@ZIF-8) demonstrates efficient adsorption of a substantial amount of doxorubicin (DOX) due to the porous nature of ZIF-8. The drug-loaded nanoparticles, Fe3O4@ZIF-8/DOX, exhibit significant accumulation at the tumor site in SW620 colon-cancer-bearing mice when guided by an external magnetic field. Within the acidic microenvironment of the tumor, the ZIF-8 framework collapses, releasing DOX and effectively inducing tumor cell death, thereby inhibiting cancer progression while not causing undesired side effects, as confirmed by a variety of in vitro and in vivo characterizations. In comparison to free DOX, Fe3O4@ZIF-8/DOX nanoparticles show superior efficacy in colon cancer treatment. Our findings suggest that Fe3O4@ZIF-8 holds promise as a carrier for small-molecule drug adsorption and its ferromagnetic properties provide drug targeting capabilities, thereby enhancing therapeutic effects on tumors at the same drug dosage. With excellent biocompatibility, Fe3O4@ZIF-8 demonstrates potential as a drug carrier in targeted cancer chemotherapy. Our work suggests that a combination of magnetic targeting and acid-responsiveness holds great promise for advancing targeted cancer therapy in precision nanomedicine.


摘要:

由于傳統(tǒng)化療藥物缺乏特異性和選擇性,其療效有限,副作用明顯,因此新的策略對于改善癌癥治療效果至關(guān)重要。在這里,我們成功地設(shè)計了包裹有沸石咪唑酸框架-8 ZIF-8)的Fe3O4磁性納米顆粒。由于ZIF-8的多孔性,所得到的納米復合材料(Fe3O4@ZIF-8)能夠有效吸附大量的阿霉素(DOX)。負載藥物的納米顆粒Fe3O4@ZIF-8/DOX在外部磁場引導下,在SW620結(jié)腸癌小鼠的腫瘤部位表現(xiàn)出顯著的積累。在腫瘤的酸性微環(huán)境中,ZIF-8框架崩潰,釋放DOX并有效誘導腫瘤細胞死亡,從而抑制癌癥進展,同時不會引起不良副作用,這一點得到了各種體外和體內(nèi)表征的證實。與游離DOX相比,Fe3O4@ZIF-8/DOX納米顆粒在結(jié)腸癌治療中表現(xiàn)出療效。我們的研究結(jié)果表明,Fe3O4@ZIF-8有望成為小分子藥物吸附的載體,其鐵磁特性提供了藥物靶向能力,從而在相同藥物劑量下增強對腫瘤的治療效果。Fe3O4@ZIF-8具有良好的生物相容性,具有作為靶向癌癥化療藥物載體的潛力。我們的工作表明,磁性靶向和酸反應性的結(jié)合對于推進精確納米醫(yī)學中的靶向癌癥治療具有很大的希望。

 

該論文中,SW620的體外培養(yǎng)是使用Ausbian特級胎牛血清完成的。


亚洲小鲜肉与欧美猛男的区别| 亚洲国产成人久久精品大牛影视| 娇妻中日久久持久久| 在线视频免费观看www动漫| 母亲6韩国电视剧免费观看| 免费a级毛片无码免费视频| 久久久国产打桩机| 亚洲国产精品无码久久一区二区| 免费a级毛片18禁网站app| 亚洲国产精品一区二区成人片国内 | 国产精品99精品无码视亚| 亚洲性av免费| 国产精品久久久久久人妻| 国产AV午夜精品一区二区入口 | 日韩精品成人无码专区免费| AV无码国产精品色午夜| 亚洲日韩av无码一区二区三区人| 无码欧美熟妇人妻影院欧美潘金莲 | 仙踪林果冻传媒一区二区| 国产午夜视频在线观看| 少妇高潮惨叫久久久久久 | 久久99精品国产麻豆不卡| 欧美最猛性XXXXX69交| 国产精品久久久久久亚洲按摩蜜桃| 欧美成人片一区二区三区| 人妻互换免费中文字幕| 欧美丰满大胆少妇xxxooo| 女人做爰全过程免费观看美女| 人妻丰满熟妇av无码区| 精品无码一区二区三区爱欲| 色欲av永久无码精品无码| 强奷人妻日本中文字幕| 国产丰满大乳大屁股A片图片| 亚洲熟妇无码一区二区三区| 色哟哟在线观看免费| 人妻斩| 国产古装妇女野外A片| av精品一区二区三区| 国产午夜视频在线观看| 亚洲精品国偷拍自产在线观看蜜臀 | 久久国产色av免费观看|